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Faculte de Medecine de Lille

Seven variant CYP4F12 allozymes characterized

Published in Genetics and Environmental Business Week, February 24th, 2005

Seven variant CYP4F12 allozymes have been identified and characterized.

"The human cytochrome CYP4F12 has been shown to be metabolically active toward inflammatory mediators and exogenous compounds such as antihistaminic drugs," according to scientists in France, who "recently identified a genetic polymorphism within the promoter region, associated with a decreased level of enzyme expression."

In their subsequent study, C. Cauffiez and coauthors at the Faculte de Medecine de Lille sought to achieve "the further identification of single nucleotide polymorphisms in the coding sequence of the CYP4F12 gene."

"A polymerase chain...

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