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Mount Sinai School of Medicine

Inherited gene may increase risk for prostate cancer by 50%

Published in Genetics and Environmental Business Week, March 10th, 2005

A single gene variant may increase a man's risk of prostate cancer by 50%, according to a new study led by researchers at Mount Sinai School of Medicine.

In 2001, Mount Sinai researchers published a study in Science that showed that a gene, known as KLF6, fails to function properly in at least 50 to 60% of all prostate cancers. This was the first single gene shown to be responsible for the majority of cases of this disease, which affects approximately 200,000 men each year.

This finding led to the question as to whether or not mutations in this gene that are present from birth might increase an individuals susceptibility to prostate cancer....

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