Published in Genetics and Environmental Business Week, December 1st, 2005
Study 1: Knockout of the neural and heart expressed gene HF-1b results in apical deficits of ventricular structure and activation.
Investigators in the United States report, "Knockout of the neural and cardiac expressed transcription factor HF-1b causes electrophysiological abnormalities including fatal ventricular arrhythmias that occur with increasing frequency around the 4th week of postnatal life. [Our] study addresses factors that may contribute to conduction disturbance in the ventricle of the HF-1b knockout mouse."
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