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ICMR Virus Unit, Kolkata

Occult HBV infection can involve higher viral load and potential infectivity

Published in Genetics and Environmental Business Week, February 2nd, 2006

A recent study from India has documented the genotype, phylogenetic analysis, and transmission pattern of occult hepatitis B virus (HBV) infection in families of asymptomatic HBsAg carriers.

"Occult hepatitis B is defined by the presence of HBV DNA in the serum in absence of hepatitis B surface antigen (HBsAg). Studies were conducted to screen for occult HBV infection among family members of HBV carriers, incidentally detected positive for HBV infection with a view to assess the pattern of virus transmission among them," wrote S. Datta and colleagues, ICMR Virus Unit.

"Nested PCR assay, employing independent sets of primers to surface and core genes,...

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