Cornell University, New York
Gene transfer of growth factor receptor suppresses pulmonary metastasis
Published in Genetics and Environmental Business Week, February 2nd, 2006
"Growth of solid tumor metastases is critically dependent on angiogenesis. We hypothesized that an angiogenic-rich milieu, as in pneumonectomy-induced lung growth, would be conducive to growth of pulmonary metastases, and that transfer of an antiangio-genic gene would suppress tumor growth," wrote M. Mae and colleagues, Cornell University.
"Two weeks after left pneumonectomy in BALB/c mice, right lung mass increased 1.5-fold compared with controls (p<.0001). Our...
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