Liver Research Center, Providence
Point mutations upstream of hepatitis B virus core gene affect DNA replication
Published in Genetics and Environmental Business Week, March 16th, 2006
"The pregenomic RNA directs replication of the HBV genome by serving both as the messenger for core protein and polymerase and as the genome precursor following its packaging into the core particle. RNA packaging is mediated by a stem-loop structure present at its 5' end designated the 6 signal, which includes the core gene initiator AUG."
"The precore RNA has a slightly extended 5' end to cover the entire precore region and,...
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