Published in Genetics and Environmental Business Week, August 31st, 2006
"The SARS coronavirus enters cells through the activities of S which has receptor-binding (S1) and membrane fusion (S2) regions. We have characterized four sequential states of a purified recombinant S ectodomain (S-e) comprising S1 and the ectodomain of S2," wrote F. Li and colleagues, Columbus Children's Hospital.
"They are S-e monomers, uncleaved S-e trimers, cleaved S-e trimers, and dissociated S1 monomers and S2 trimer rosettes. Lowered pH induces an irreversible transition from...
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