Published in Genetics and Environmental Business Week, October 19th, 2006
"Serum transferrin reversibly binds iron in each of two lobes and delivers it to cells by a receptor-mediated, pH-dependent process. The binding and release of iron result in a large conformational change in which two subdomains in each lobe close or open with a rigid twisting motion around a hinge," wrote J. Wally and colleagues, National Institute of Diabetes & Digestive & Kidney Diseases.
"We report the structure of human serum transferrin (hTF) lacking iron (apo-hTF),...
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