Virology

New findings reported from Iowa State University, Pathology Department describe advances in virology

Published in Genetics and Environmental Business Week, November 16th, 2006

Current study results from the report, "trans regulation of cap-independent translation by a viral subgenomic RNA," have been published. "Many positive-strand RNA viruses generate 3'-coterminal subgenomic mRNAs to allow translation of 5'-distal open reading frames. It is unclear how viral genomic and subgenomic mRNAs compete with each other for the cellular translation machinery," scientists in the United States report.

"Translation of the uncapped Barley yellow dwarf virus genomic RNA (gRNA) and subgenomic RNA1 (sgRNA1) is driven by the powerful cap-independent translation element (BTE) in their 3' untranslated regions (UTRs). The BTE forms a kissing stem-loop...

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Source: Genetics and Environmental Business Week (2006-11-16)

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