Parkinson Disease Genetics

Research conducted at Brigham and Women's Hospital, Department of Pathology has provided new information about parkinson disease genetics

Published in Genetics and Environmental Business Week, November 23rd, 2006

Fresh data on Parkinson disease are presented in the report "Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity." According to recent research from the United States, "Alpha-synuclein is a neuronal protein implicated genetically in Parkinson's disease. alpha-synuclein localizes to the nucleus and presynaptic nerve terminals. Here we show that alpha-synuclein mediates neurotoxicity in the nucleus."

"Targeting of alpha-synuclein to the nucleus promotes toxicity, whereas cytoplasmic sequestration is protective in both cell culture and transgenic Drosophila. Toxicity of alpha-synuclein can be...

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Source: Genetics and Environmental Business Week (2006-11-23)

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