Fresh data on Parkinson disease are presented in the report "Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity." According to recent research from the United States, "Alpha-synuclein is a neuronal protein implicated genetically in Parkinson's disease. alpha-synuclein localizes to the nucleus and presynaptic nerve terminals. Here we show that alpha-synuclein mediates neurotoxicity in the nucleus."
"Targeting of alpha-synuclein to the nucleus promotes toxicity, whereas cytoplasmic sequestration is protective in both cell culture and transgenic Drosophila. Toxicity of alpha-synuclein can be...
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