Carcinogenesis
Reports outline carcinogenesis study findings from National Center for Toxicological Research, Research Division
Published in Genetics and Environmental Business Week, April 5th, 2007
A report, "Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis," is newly published data in Molecular Carcinogenesis. "Tamoxifen, a nonsteroidal anti-estrogen, is a potent genotoxic hepatocarcinogen in rats, with both tumor initiating and promoting properties. Recently it has been demonstrated that genotoxic carcinogens, in addition to exerting genotoxic effects, often cause epigenetic alterations and these induced epigenetic changes may play important mechanistic role in carcinogenesis," scientists writing in the journal Molecular Carcinogenesis report.
"In the present study, we investigated the role of tamoxifen-induced...
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