Gene Therapy

Study findings from K.H. Wang et al provide new insights into gene therapy

Published in Genetics and Environmental Business Week, October 25th, 2007

According to recent research published in the journal Nature Biotechnology, "'In vivo incorporation of unnatural amino acids by amber codon suppression is limited by release factor-1-mediated peptide chain termination. Orthogonal ribosome- mRNA pairs function in parallel with, but independent of, natural ribosomes and mRNAs."

"Here we show that an evolved orthogonal ribosome (ribo-X) improves tRNA(CUA)-dependent decoding of amber codons placed in orthogonal mRNA. By combining ribo-X, orthogonal mRNAs and orthogonal aminoacyl-tRNA synthetase/tRNA pairs in Escherichia coli, we increase the efficiency of site-specific unnatural amino acid incorporation from similar...

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Source: Genetics and Environmental Business Week (2007-10-25)

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