Genetics & Environmental Business Week
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Gene Therapy
New findings in gene therapy described from RIKEN
November 22nd, 2007
"Dendritic filopodia are long, thin, actin-rich, and dynamic protrusions that are thought to play a critical role as a precursor of spines during neural development. We reported previously that a telencephalon-specific cell adhesion molecule, telencephalin (TLCN) [intercellular adhesion molecule-5 (ICAM-5)], is highly expressed in dendritic filopodia, facilitates the filopodia formation, and slows spine maturation," scientists writing in the Journal of Neuroscience report. "Here we demonstrate that TLCN cytoplasmic region binds ERM (ezrin/radixin/moesin) family proteins that link membrane proteins to actin cytoskeleton. In cultured hippocampal neurons,...
Source: Genetics & Environmental Business Week (2007-11-22)
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