Genetics & Environmental Business Week
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Gene Therapy
Reports from Merck & Company, Inc., Department of Molecular advance knowledge in gene therapy
November 22nd, 2007
Data detailed in 'A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling' have been presented. "The orphan nuclear receptor Nurr1 is essential for the development and maintenance of midbrain dopaminergic neurons, the cells that degenerate during Parkinson's disease, by promoting the transcription of genes involved in dopaminergic neurotransmission. Since Nurr1 lacks a classical ligand-binding pocket, it is not clear which factors regulate its activity and how these factors are affected during disease pathogenesis," scientists in the United States report. "Since Wnt signaling via beta-catenin promotes the differentiation of...
Source: Genetics & Environmental Business Week (2007-11-22)
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