Genetics & Environmental Business Week
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Acute Lymphoblastic Leukemia
Scientists at West Virginia University, Mary Babb Randolph Cancer Center target acute lymphoblastic leukemia
November 22nd, 2007
New research, 'Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells,' is the subject of a report. According to recent research from the United States, "Although leukemic stem cells (LSCs) show a symbiotic relationship with bone marrow microenvironmental niches, the mechanism by which the marrow microenvironment contributes to self-renewal and proliferation of LSCs remains elusive. In the present study, we identified a unique subpopulation of Philadelphia chromosome-positive (Ph(+)) acute lymphoblastic leukemia (ALL) cells coexpressing markers of endothelial cells (including VE-cadherin, PECAM-1, and Flk-1) and...
Source: Genetics & Environmental Business Week (2007-11-22)
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