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Antisense Technology
Research on antisense technology described by scientists at National Institute of Allergy and Infectious Disease
November 22nd, 2007
A report, 'Episomally driven antisense mRNA abrogates the hyperinducible expression and function of a unique cell surface class I nuclease in the primitive trypanosomatid parasite, Crithidia luciliae,' is newly published data in JMB Online. "Here, we show that Crithidia luciliae, a primitive trypanosomatid, purine auxotroph, up-expressed its unique, bi-functional, surface membrane 3'-nucleotidase/nuclease (Cl 3'NT/NU) activity by approximately 1000-fold in response to purine starvation. A second surface membrane phospho-monoesterase, i.e. a tartrate-resistant acid phosphatase (Cl MAcP) was also found to be up-expressed in such purine-starved cells," investigators in the United...
Source: Genetics & Environmental Business Week (2007-11-22)
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