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B-Cell Lymphoma Genetics
Research conducted at University of Texas, M.D. Anderson Cancer Center has updated our knowledge about B-cell lymphoma genetics
November 22nd, 2007
Scientists discuss in 'WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy' new findings in B-cell lymphoma. "WWOX is a putative tumor suppressor gene encoded within common chromosomal fragile site region FRA16D, in chromosome band 16q23. Multiple studies have demonstrated that WWOX expression is often reduced or lost in various tumor types," scientists in the United States report. "WWOX tumor suppressor activity was suggested by re-expressing WWOX in breast, ovarian, and lung tumor cell lines leading to tumor growth inhibition in vivo. To determine whether loss of Wwox gene expression has a role in tumorigenesis, we...
Source: Genetics & Environmental Business Week (2007-11-22)
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