Genetics & Environmental Business Week
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B-Cell Lymphoma Immunology
New findings from Kyoto University in the area of B-cell lymphoma immunology described
November 22nd, 2007
Data detailed in 'Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice' have been presented. "LYL1, a member of the class II basic helix-loop-helix transcription factors, is aberrantly expressed in a fraction of human T-cell acute lymphoblastic leukemia. Here, we generated transgenic mice ubiquitously overexpressing LYL1 using a construct expressing full-length cDNA driven by a human elongation factor 1alpha promoter," scientists in Kyoto, Japan report. "Four independent lines exhibiting high LYL1 expression were established. Of these transgenic mice, 96% displayed loss of hair with a short kinked tail. Furthermore, 30% of them developed...
Source: Genetics & Environmental Business Week (2007-11-22)
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