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Genetics & Environmental Business Week

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Bioconversion



Findings from Seoul National University in bioconversion reported



November 22nd, 2007

New research, 'Bioconversion of 12-, 14-, and 16-membered ring aglycones to glycosylated macrolides in an engineered strain of Streptomyces venezuelae,' is the subject of a report. According to recent research published in the journal Applied Microbiology and Biotechnology, "To develop a system for combinatorial biosynthesis of glycosylated macrolides, Streptomyces venezuelae was genetically manipulated to be deficient in the production of its macrolide antibiotics by deletion of the entire biosynthetic gene cluster encoding the pikromycin polyketide synthases and desosamine biosynthetic enzymes. Two engineered deoxysugar biosynthetic pathways for the biosynthesis of thymidine...


Source: Genetics & Environmental Business Week (2007-11-22)

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