RNA Research

Findings in RNA research reported from University of Iowa

Published in Genetics and Environmental Business Week, February 28th, 2008

"The Trypanosoma brucei genome encodes three groups of zinc metalloproteases, each of which contains similar to 30% amino acid identity with the major surface protease (MSP, also called GP63) of Leishmania. One of these proteases, TbMSP-B, is encoded by four nearly identical, tandem genes transcribed in both bloodstream and procyclic trypanosomes," scientists in the United States report.

"Earlier work showed that RNA interference against TbMSP-B prevents release of a recombinant variant surface glycoprotein (VSG) from procyclic trypanosomes. Here, we used gene deletions to show that TbMSP-B and a phospholipase C (GPI-PLC) act in concert to remove native VSG during...

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Source: Genetics and Environmental Business Week (2008-02-28)

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