Gene Therapy
Data on gene therapy described by researchers at University of California
Published in Genetics and Environmental Business Week, March 13th, 2008
Investigators publish new data in the report 'Distinct CD8+ T cell repertoires primed with agonist and native peptides derived from a tumor-associated antigen.' "Heteroclitic peptides are used to enhance the immunogenicity of tumor-associated Ags to break T cell tolerance to these self-proteins. One such altered peptide ligand (Cap1-6D) has been derived from an epitope in human carcinoembryonic Ag, CEA(605-613) (Cap1)," scientists in the United States report.
"Clinical responses have been seen in colon cancer patients receiving a tumor vaccine comprised of this altered peptide. Whether Cap1-6D serves as a T cell agonist for Cap1-specific T cells or induces different T...
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