Gene Therapy

Study findings from University of Leuven provide new insights into gene therapy

Published in Genetics and Environmental Business Week, May 1st, 2008

According to recent research from Louvain, Belgium, "The Mrr protein of Escherichia coli K12 is a cryptic type IV restriction endonuclease with specificity for methylated DNA. Recently it was discovered that endogenous activation of E. coli Mrr could be triggered by high pressure stress, resulting in the generation of double strand breaks in the host chromosome and concomitant induction of the SOS response."

"In this report we focused on Mrr activity of Salmonella Typhimurium LT2, and although we surprisingly found no evidence of high pressure induced activation, a large number of constitutively activated Mrr mutants could be isolated when the mrr gene was routinely...

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Source: Genetics and Environmental Business Week (2008-05-01)

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