Acute Lymphoblastic Leukemia

St. Jude Discovery Offers New Avenues to Understanding an Aggressive Form of Leukemia

Published in Genetics and Environmental Business Week, May 1st, 2008

Researchers at St. Jude Children's Research Hospital have discovered evidence that a series of genetic mutations work together to initiate most cases of an aggressive and often-fatal form of acute lymphoblastic leukemia (ALL).

These defects, known as "cooperating oncogenic lesions," include the deletion of a gene, IKZF1, whose protein, Ikaros, normally helps guide the development of a blood stem cell into a lymphocyte. The researchers also found that loss of the same gene accompanied the transformation of chronic myelogenous leukemias (CMLs) to a life-threatening acute stage.

"These findings provide new avenues to pursue to gain a better...

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Source: Genetics and Environmental Business Week (2008-05-01)

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