Acute Lymphoblastic Leukemia

Scientists at Medical University of Innsbruck publish research in acute lymphoblastic leukemia

Published in Genetics and Environmental Business Week, May 15th, 2008

According to a study from Innsbruck, Austria, "Glucocorticoid (GC)-induced apoptosis is essential in the treatment of acute lymphoblastic leukemia (ALL) and related malignancies. Pro-and anti-apoptotic members of the BCL2 family control many forms of apoptotic cell death, but the extent to which this survival 'rheostat' is involved in the beneficial effects of GC therapy is not understood."

"We performed systematic analyses of expression, GC regulation and function of BCL2 molecules in primary ALL lymphoblasts and a corresponding in vitro model. Affymetrix-based expression profiling revealed that the response included regulations of pro-apoptotic and, surprisingly,...

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Source: Genetics and Environmental Business Week (2008-05-15)

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