Bone Research
Researchers at Arizona State University target bone research
Published in Genetics and Environmental Business Week, May 29th, 2008
"The vitamin D hormone, 1,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes. 1,25(OH)(2)D-3 is known primarily as a regulator of calcium, but it also controls phosphate (re)absorption at the intestine and kidney. Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone produced in osteoblasts that, like PTH, lowers serum phosphate by inhibiting renal reabsorption through Npt2a/Npt2c," scientists in the United States report.
"Real-time PCR and reporter gene transfection assays...
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