Gene Therapy

Research from University of Portsmouth in the area of gene therapy described

Published in Genetics and Environmental Business Week, August 28th, 2008

"Poor nuclear entry, especially into nondividing cells, is a limiting factor in nonviral gene delivery. We have engineered a novel chimeric vector relying on the controlled assembly of a TAT-tagged multisubunit DNA binding protein (EcoR124I) with expression plasmids containing the EcoR124I recognition site," scientists writing in the Faseb Journal report.

"Molecular interactions of this molecular assembly were studied by electrophoretic mobility shift assay and atomic force microscopy. Maintenance of nanocomplexes in an appropriate stoichiometric ratio was both necessary and sufficient to produce a significant (> 8-fold) increase in the activity of the...

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Source: Genetics and Environmental Business Week (2008-08-28)

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