Myasthenia Gravis

Investigators at Peking University publish new data on myasthenia gravis

Published in Genetics and Environmental Business Week, August 28th, 2008

"Ciclosporin (CsA), which is widely used in autoimmune disease and transplantation, has a narrow therapeutic index. It also shows considerable interindividual variability in its pharmacokinetics, which may be attributable to polymorphisms of the multidrug efflux pump P-glycoprotein, encoded by MDR-1," researchers in Beijing, People's Republic of China report.

"The aim was to determine the role of genetic polymorphisms in MDR-1 with respect to interindividual variability of CsA blood concentrations in myasthenia gravis (MG) patients. MG patients (n = 129) receiving CsA were genotyped for MDR-1 1236C-- >T (exon 12), 2677G-- >T (exon 21) and 3435C-- >T (exon 26)....

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Source: Genetics and Environmental Business Week (2008-08-28)

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