Leukemia

Reports summarize leukemia research from T. Hara and co-authors

Published in Genetics and Environmental Business Week, September 18th, 2008

"Identifying genetic pathways that cooperate in leukemo-genesis facilitates our understanding of the molecular mechanisms at play. Interferon consensus sequence-binding protein ( ICSBP) is a tumor suppressor, whose downregulation cooperates with BCR-ABL and NUP98-TOP1 gene products to accelerate leukemia induction in mouse models," scientists in Tokyo, Japan report.

"Similarly, Meis1 synergizes with HoxA9 or NUP98-HOX ( but not NUP98-TOP1) fusion genes to promote the early onset of leukemia. To investigate whether Icsbp deficiency interacts with Meis1 or its family member Meis3, we transplanted Icsbp -/- bone marrow ( BM) cells after transduction with Meis1 or Meis3...

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Source: Genetics and Environmental Business Week (2008-09-18)

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