Gene Therapy

Data on gene therapy described by S. Ehira et al

Published in Genetics and Environmental Business Week, October 2nd, 2008

"The sigB gene of Corynebacterium glutamicum encodes a group 2 sigma factor of RNA polymerase. Under conditions of oxygen deprivation, the sigB gene is upregulated and cells exhibit high productivity of organic acids as a result of an elevated glucose consumption rate," investigators in Kyoto, Japan report.

"Using DNA microarray and quantitative reverse transcription-PCR (RT-PCR) analyses, we found that sigB disruption led to reduced transcript levels of genes involved in the metabolism of glucose into organic acids. This in turn resulted in retardation of glucose consumption by cells under conditions of oxygen deprivation. These results indicate that SigB is involved...

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Source: Genetics and Environmental Business Week (2008-10-02)

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