Antisense Technology

Research on antisense technology described by scientists at RIKEN

Published in Genetics and Environmental Business Week, October 2nd, 2008

"Nkx2.2AS is an endogenous antisense transcript to Nkx2.2 gene, subcellularly located in the cytoplasm. We tested if Nkx2.2AS transcripts have any biological function by regulating transcription level of Nkx2.2 coding gene in the differentiation of neural stem cells," scientists in Yokohama, Japan report.

"Forced expression of Nkx2.2AS in neural stem cells enhanced induction of differentiation along lineage of oligodendrocytes. Further analyses showed that overexpression of Nkx2.2AS induced modest increase in Nkx2.2 mRNA level, suggesting that the upregulation of Nkx2.2 mRNA level can be a minor cause of enhanced induction of oligodendrocytic differentiation by Nkx2.2AS...

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Source: Genetics and Environmental Business Week (2008-10-02)

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