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Cancer Cell Biology
Study data from Kyushu University, Medical Institute of Bioregulation update knowledge of cancer cell biology
July 16th, 2009
New research, 'Level of reactive oxygen species induced by p21 is critical for the determination of cell fate,' is the subject of a report. "p21(WAF(1)/)(CIP(1)) is a well-known cell cycle regulatory protein which is overexpressed in several cancer cell lines, and known to determine cell fate. We generated three recombinant adenovirus vectors that expressed either the full-length p21 (Ad-p21F), a p21 mutant with a deletion of the C-terminal proliferative cell nuclear antigen (PCNA) binding domain (Ad-p21N), or a p21 mutant with a deletion of the N-terminal cyclin-dependent kinase binding domain (Ad-p21C)," scientists in Fukuoka, Japan report. "We transfected these...
Source: Genetics & Environmental Business Week (2009-07-16)
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