Immunization

New immunization data have been reported by researchers at University of Heidelberg

Published in Genetics and Environmental Business Week, July 30th, 2009

"Dendritic cells (DCs) are professional antigen presenting cells and have key functions in the initiation of immune responses. Hence, antigen-loaded DCs have become important tools for active-specific immunotherapy," scientists in Heidelberg, Germany report.

"In addition to defining strategies for antigen loading, effective T-cell activation by DCs will depend on vaccination protocols that facilitate DC migration to secondary lymphoid tissues and expression of costimulatory molecules and cytokines. Adenoviral gene transfer has been Successfully implemented for genetic antigen loading of DCs. In this study, we exploit an adenoviral vector encoding human CD40 ligand...

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Source: Genetics and Environmental Business Week (2009-07-30)

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