RNA Research
Research on RNA research discussed by scientists at Aarhus University
Published in Genetics and Environmental Business Week, August 13th, 2009
According to a study from Aarhus, Denmark, "The use of systemic siRNA therapeutics for RNA interference-mediated silencing of disease genes is limited by serum instability and inadequate biodistribution. We have previously reported on the EGFP gene silencing effect of chitosan/siRNA nanoparticles in the bronchoepithelium of mice lungs following intranasal delivery and improved serum stability and reduced off-targeting effects in vitro by incorporation of locked nucleic acid (LNA)."
"In this study, we examine the pulmonary gene silencing effect of siLNAs targeting enhanced-greenfl uorescent-protein (EGFP) in lung bronchoepithelium upon intravenous delivery of naked...
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