Small-vessel Disease

New findings in small-vessel disease described from Leiden University

Published in Genetics and Environmental Business Week, August 13th, 2009

"Basal total cerebral blood flow (TCBF) and cerebrovascular reactivity (CVR) are assumed to play an important role in the pathophysiology of small-vessel disease. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a unique monogenetic model to study the pathophysiology of arterial small-vessel disease," scientists writing in the American Journal of Neuroradiology report.

"The aim of this study was to investigate the role of TCBF and CVR in the progression of MR imaging abnormalities in CADASIL. Basal TCBF was measured in 25 NOTCH3 mutation carriers and 13 control subjects at baseline. CVR after administration...

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Source: Genetics and Environmental Business Week (2009-08-13)

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