Gastric Cancer Genetics
New gastric cancer genetics research reported from University of Porto, Institute of Molecular Pathology and Immunology
Published in Genetics and Environmental Business Week, March 11th, 2010
A report, 'Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer,' is newly published data in Human Molecular Genetics. According to recent research from Porto, Portugal, "Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer susceptibility syndrome characterized by early-onset diffuse gastric cancer (DGC) and lobular breast cancer. E-cadherin (CDH1) heterozygous germline mutations and deletions are found in 40% of families."
"Independent of CDH1 alterations, most HDGC tumours display mislocalized or absent E-cadherin immunoexpression, therefore undetected defects at the CDH1 locus may still be involved. We aimed at...
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