Adenocarcinoma

Studies from G. Liu et al add new findings in the area of adenocarcinoma

Published in Genetics and Environmental Business Week, March 11th, 2010

According to recent research from Toronto, Canada, "p53 Arg72Pro, MDM2 T309G, and CCND1 G870A are functional single-nucleotide polymorphisms ( SNPs) in key genes that regulate apoptosis and cell cycle. Variant genotypes of these SNPs have been associated with increased risk and earlier age of onset in some cancers."

"We investigated the association of these SNPs with susceptibility to esophageal adenocarcinoma in a large, North American case-control study. Three hundred and twelve cases and 454 cancer-free controls recruited in Boston, USA were genotyped for each of the three SNPs, and demographic and clinical data were collected. Genotype frequencies for each of the...

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Source: Genetics and Environmental Business Week (2010-03-11)

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