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Gastric Cancer Genetics

New findings from Shanghai JiaoTong University in the area of gastric cancer genetics described

Published in Genetics and Environmental Business Week, March 18th, 2010

Researchers detail in 'Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner,' new data in gastric cancer. "The transcription factor Foxp3 plays a key role in CD4(+)CD25(+) regulatory T (Treg) cell function. A correlation has been shown between survival and the frequency of tumor-infiltrating Foxp3-positive Treg cells in cancer patients," researchers in People's Republic of China report.

"However, few studies have characterized the regulation of Foxp3 expression and function in Treg cells, which are known to comprise distinct subsets, with different roles in...

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