Breast Cancer
Synthetic lethality: a new way to kill cancer cells
Published in Genetics and Environmental Business Week, March 18th, 2010
Susan Bates and Christina Annunziata looked at several recent papers on this form of treatment, which takes advantage of the synthetic lethality of BRCA (breast cancer susceptibility genes) and poly-ADP ribose polymerase (PARP) proteins to attack cancerous cells whilst sparing healthy ones.
BRCA and PARP are two key players in DNA repair and have different but complementary functions in the cell. Loss of the BRCA protein...
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