Metabolism
Research from University of Toronto has provided new information about metabolism
Published in Genetics and Environmental Business Week, March 18th, 2010
A new study, 'Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors,' is now available. "We investigated the role of genetic, physiological, environmental, and epigenetic factors in regulating CYP2A6 expression and nicotine metabolism. Human livers (n=67) were genotyped for CYP2A6 alleles and assessed for nicotine metabolism and CYP2A6 expression (mRNA and protein)," investigators in Canada report.
"In addition, a subset of livers (n=18), human cryopreserved hepatocytes (n=2), and HepG2 cells were used for DNA methylation analyses. Liver samples with variant CYP2A6 alleles had significantly lower CYP2A6...
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