University of Oxford
Crystal structures of NNRT-resistant HIV RT characterized
Published in Genetics and Environmental Health Week, March 31st, 2004
"Leu100Ile, Val106Ala and Val108Ile are mutations in HIV-1 reverse transcriptase (RT) that are observed in the clinic and give rise to resistance to certain non-nucleoside inhibitors (NNRTIs) including the first-generation drug nevirapine," scientists in England explained.
"In order to investigate structural mechanisms of resistance for different NNRTI classes," J. Ren and colleagues at the University of Oxford "determined six crystal structures of mutant RT-inhibitor complexes."
"Val108 does not have direct contact with nevirapine in...
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