Published in Genetics and Environmental Health Week, January 5th, 2005
The primary genetic cause of Rett syndrome is a mutation in the gene MECP2, encoding a protein thought generally to affect the expression of many other genes, several of which probably contribute to the disease. The search for MECP2 "target" genes that are relevant to the development of Rett syndrome has been difficult, but Terumi Kohwi-Shigematsu and colleagues at Lawrence Berkeley Laboratory have now identified the gene DLX5 as a strong candidate....
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