M.D. Anderson Cancer Center
The cancer-specific properties of the survivin promoter enhance gene transfer
Published in Genetics and Environmental Health Week, January 12th, 2005
According to a study from the United States, "survivin is expressed in many cancers but not in normal adult tissues and is transcriptionally regulated. To test the feasibility of using the survivin promoter to induce cancer-specific transgene expression in lung cancer gene therapy, a vector expressing a luciferase gene driven by the survivin promoter was constructed and evaluated in vitro and in vivo."
"We found that the survivin promoter was generally more highly activated in cancer cell lines than in normal and immortalized normal cell lines," reported J.S. Chen and...
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