Hospital Ramon y Cajal, Madrid
Transcription factor expression characterized in clinical tumor samples
Published in Genetics and Environmental Health Week, February 2nd, 2005
"Hodgkin lymphoma can be considered in most cases a B-cell lymphoma due to the presence of potentially functional immunoglobulin (Ig) gene rearrangements in the neoplastic cells," pathologists in Spain noted. "In contrast to lymphocyte-predominant Hodgkin lymphoma, Hodgkin/Reed-Sternberg (HRS) cells from classical Hodgkin lymphoma have low frequency of B-cell marker expression and lack Ig light and Ig heavy messenger RNA."
"Recent studies have shown transcription machinery deficiency in Hodgkin lymphoma caused by an absence of the...
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