U.S. National Institutes of Health
Quiescent neural stem cells can self-renew for over a year and generate multiple cell types
Published in Genetics and Environmental Health Week, December 7th, 2005
"Sonic hedgehog (Shh) has been implicated in the ongoing neurogenesis in postnatal rodent brains. Here we adopted an in vivo genetic fate-mapping strategy, using Gli1 (GLI-Kruppel family member) as a sensitive readout of Shh activity, to systematically mark and follow the fate of Shh-responding cells in the adult mouse forebrain," investigators in the United States report.
"We show that initially, only a small population of cells (including both quiescent neural stem cells and transit-amplifying cells) responds to Shh in regions undergoing...
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