Published in Genetics and Environmental Health Week, September 20th, 2006
This finding sheds light on a puzzling behavior. For some differentiating stem cells, the first step leads not to a final decision but to a new choice. In response to the initial chemical signal, these cells take on the genetic signatures of two different cell types. It often requires a second signal for them to commit to a single cellular identity.
In a recent issue of Cell, the researchers, working with hematopoietic stem cells, which give rise to the many types of blood cells, show how...
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