Graz University, Austria
Researchers from Austria, Italy and the South Korea describe findings in diabetes studies
Published in Genetics and Environmental Health Week, September 20th, 2006
Study 1: Blocking ETA receptors ameliorates myocardial, coronary and renal function in a type 1 diabetes model.
According to a study from Austria, "We investigated the roles of nitric oxide (NO) and endothelin-1 (ET-1) in organ dysfunction in diabetic mice with normal genotype (wild-type, WT) or myocyte-specific overexpression of endothelial NO synthase (eNOS) (transgenic, TG) after chronic oral treatment with the endothelin-A(ET A) receptor antagonist atrasentan."
"Mice were rendered diabetic by injection of 200 mg/kg streptozotocin (STZ)....
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