Boston University, U.S.
Reports outline epilepsy genetics study findings from Boston University, Department of Pharmacology
Published in Genetics and Environmental Health Week, November 1st, 2006
Researchers detail in "Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha4 subunits in hippocampal neurons," new data in epilepsy. "Altered function of gamma-aminobutyric acid type A receptors (GABA(A)Rs) in dentate granule cells of the hippocampus has been associated with temporal lobe epilepsy (TLE) in humans and in animal models of TLE. Such altered receptor function (including increased inhibition by zinc and lack of modulation by benzodiazepines) is related, in part, to changes in the mRNA levels of certain GABA(A)R subunits, including alpha4, and may play a role in epileptogenesis,"...
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