Columbus Children's Hospital, Cincinnati, U.S.
B-precursor childhood acute lymphoblastic leukemia linked to perforin polymorphism A91V
Published in Genetics and Environmental Health Week, November 1st, 2006
"Perforin plays a key role in the cytotoxicity of natural killer and cytotoxic T cells. Genetic mutations in PRF1 give rise to approximately 30% cases of familial hemophagocytic lymphohistiocytosis," scientists in the United States reported.
"A frequent polymorphism, A91V (C to T transition at position 272), may impair processing of perforin protein to the active form, and has been suggested to increase susceptibility to childhood ALL," explained P.A. Mehta and colleagues, Columbus Children's Hospital. "To...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Genetics and Environmental Health Week
More Articles from Genetics and Environmental Health Week
- Aarhus University, Denmark
Reports outline heart disease epidemiology study results from Aarhus University - Aarhus University, Denmark
Research on pneumococcal disease epidemiology published by scientists at Aarhus University, Department of Clinical Biochemistry - Aarhus University, Denmark
Studies from Aarhus University, Medical Department describe new findings in type 2 diabetes risk factors - Academia Sinica, Taiwan
Studies from Taiwan, Singapore and France add new findings to hepatocellular carcinoma body of knowledge - Academic Medical Center, Amsterdam, Netherlands
Reports from Academic Medical Center, Department of Cardiology add new data to research in heart disease risk factors - Adcock Ingram
Belgium is latest European country to propose smoking ban - More from this issue of Genetics and Environmental Health Week
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
