Diabetes Pathogenesis
Thymic proinsulin expression is probably Pdx-1 independent
Published in Genetics and Environmental Health Week, November 15th, 2006
"Proinsulin, like many tissue-specific antigens, is expressed by rare (1-3%) cells of the thymus medullary stroma, presumably for the purpose of self-tolerance. Levels of this expression are associated with type 1 diabetes susceptibility in humans and in the NOD mouse," scientists in Canada report.
M.O. Palumbo and colleagues at McGill University explained, "To further understand the mechanism of central tolerance induction by these rare cells, we have isolated and cultured two proinsulin-producing epithelial cell clones from murine thymus. These cells have a typical epithelial morphology...
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