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Brain Cancer

Glioma-produced extracellular matrix influences brain tumor tropism of neural stem cells

Published in Genetics and Environmental Health Week, November 15th, 2006

Glioma-produced extracellular matrix influences brain tumor tropism of neural stem cells.

"A major obstacle in the treatment of gliomas is the invasive capacity of the tumor cells. Previous studies have demonstrated the capability of neural stem cells (NSCs) to target these disseminated tumor cells and to serve as therapeutic delivery vehicles.

"Less is known about the factors involved in brain tumor tropism of NSCs and their interactions within the tumor environment," wrote scientists in the United States.

According to M. Ziu and colleagues at Brigham & Women's Hospital in Boston, "As gliomas progress and invade, an extensive...

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